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About the Author: Leah Furman is an author and lecturer who has appeared on many radio and television programs, including Good Morning America. From Publishers Weekly: Shoyn Tsayt.
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It s about time someone put together a candid, thoughtful, representative book on dating for nice and not so nice Jewish girls. Her exhaustive research and insightful examples ensure that any Jewish girl will find something that evokes a smile of recognition. Thus, future research on the impact of interactions among social, behavioral, and genetic factors on health must determine which of these facets and dimensions contribute directly to sex differences in health and which are merely correlates.
They have testes and hormone levels higher than those of pubertal boys. But, because their androgen receptors do not bind androgen, their genitalia, secondary sex characteristics, and musculature are fully differentiated as women.
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Until the Olympic committee changed its definition of sex from genetic to hormonal sex, such women had to compete as men. However, their social roles—as actresses or Olympic athletes, for example— are better predictors of cardiovascular health and risk for muscle injury.
The constructs of race and ethnicity, which have similar limitations and complexity as sex and gender, are explored in the following section. With the increased attention being given to racial disparities in health, the definition of race has come under increased scientific scrutiny.
Race also is notoriously difficult to define and is inconsistently reported in the literature and in self-reports. Self-report has been the classic measure for race and is still reliable in some cases given certain caveats. The usefulness of the data derived from self-reports of race in health research, however, has been the subject of much debate Risch et al.
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Erecting barriers to the collection of information such as race and ethnic background may provide protection against the aforementioned risks; however, it will simultaneously retard progress in biomedical research and limit the effectiveness of clinical decision-making.
NIH has prescribed that all research projects will involve a good faith effort to include minorities when appropriate. By requiring funded research to make appropriate accommodations for minority subject recruitment, NIH has encouraged scientists to begin to consider issues of race, ethnicity, and culture in research as never before.
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Some of the emphasis on learning more about minority populations arises from the acknowledgement of the stark disparities in health when comparisons are made across racial groups. Furthermore, it also appears that African Americans are less likely to survive to middle age, and if they do, they are more likely to have health problems Hayward et al.
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Health disparities are a major public health concern and are a major emphasis of research across the country and across many disciplines. It is only by studying the multiple levels and risk factors simultaneously within subgroups defined by ethnicity, geography, genetic backgrounds, and exposures to the environment that we will begin to understand how specific combinations of environmental factors combine with specific combinations of genetic factors to give rise to health differences.
Despite the complexities and care that must be taken in attributing phenotypic differences to genetic differences among races, much may be gained by focusing on disorders that occur more frequently within a well-defined more SNPs may affect a given phenotype at multiple levels so that a given protein is altered in its sequence, in its proper place in the organism, and in its proper development time.
A part of the promoter may be altered such that a protein is absent in some of its normal tissues but not in others or is present in the wrong tissue or at the wrong time.
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An mRNA splice site may be altered such that protein isoforms are inappropriately expressed in a given tissue. A target sequence may be altered leading to aberrant targeting of the protein to cellular compartments. Finally, an epigenetic mechanism may be altered leading to changes in developmental timing of a particular protein.
Due to evolutionary history, sequence is more highly conserved in cod ing regions when compared to noncoding regions.
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This feature creates the following situation in the genetic research of traits of great importance for public health: the interactions of SNPs with environment will be subtle and so will require large studies comprised of large cohorts carefully phenotyped for large numbers of environmental factors and genotyped for thousands of SNPs.
Yet another challenge facing investigation using SNPs is that the bulk of SNPs found are not located in the conserved coding regions. Arguments that genetic factors cannot be a major cause of health disparities arise out of a paradigm of genetic research that focuses on independent effects of genetics. Research on health disparities is an important opportunity to integrate biological knowledge with social and behavioral knowledge in order to better understand the determinants of disease.
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Conversely, solely focusing on molecular genetics ignores the dynamic nature of populations of DNA and the complex relationships among genes, organisms, and environment. Considerable literature exists concerning how environmental processes, events, and circumstances contribute to development and behavior in ways that influence health as well.
Some of these environmental factors are negative and are found to be more prevalent in the development of minorities. Sources of individual differences in health and behavior in African Americans have implications for the quality of late life as well as quantity of late life years of life remaining.
Conversely, the groups within the Hispanic category significantly differ in their regional concentrations in the United States